Amino acids may sound like highly sophisticated scientific molecules, which they are. But they also show up in practically all the foods we eat, in varying quantities.
Amino acid supplements are being touted as solutions for everything from anxiety to weight loss, but are they safe? Should you take them, and do you need them? Here’s the lowdown.
So, what exactly are amino acids?
It’s not in any way an exaggeration to refer to amino acids as the building blocks of life. All proteins are composed of amino acids, including our DNA. This makes them pretty darn important!
Amino acids can be broadly divided into two categories: essential and nonessential. Don’t let the name fool you—nonessential amino acids are incredibly important—it’s just that our bodies are not able to synthesize essential amino acids, so it’s essential that we get them in our diet.
There are 20 amino acids in total, 9 of which are essential:
- Histidine
- Isoleucine
- Leucine
- Lysine
- Methionine
- Phenylalanine
- Threonine
- Tryptophan
- Valine
And the rest are nonessential:
- Alanine
- Arginine*
- Asparagine
- Aspartic acid
- Cysteine*
- Glutamic acid
- Glutamine*
- Glycine
- Pyrrolysine*
- Proline*
- Selenocysteine*
- Serine*
- Tyrosine*
Some of the nonessential amino acids, however, are considered conditionally essential (indicated with *) because they are essential only in some cases, such as during certain illnesses. Some of the conditionally essential amino acids are essential in children but not adults.
How do amino acids work, and what do they do?
The way amino acids work in our bodies is that when you ingest a protein, your body breaks it apart into its individual amino acids, reorders them, refolds them, and turns them into whatever is needed at the time. Nonessential amino acids are produced in the liver through a process known as transamination.
Amino acids build cells, repair tissues, produce enzymes, and play a key role in our health and well-being. They contribute to blood sugar regulation, energy levels, memory and cognitive behavior, stress responses, and muscle building and repair. Nonessential amino acids also play a role in immune system function, metabolism, and digestion.
Are amino acid supplements a good idea?
In general, we can meet our basic amino acid needs through a balanced diet. Animal proteins such as meat, eggs, fish, and dairy contain all 9 essential amino acids in the amounts that we need. Plant-based proteins also contain all 9, but are often low in one or more essential amino acids.
For example, most beans are low in methionine and high in lysine, whereas rice is low in lysine and high in methionine. The old adage that vegetarians should combine complementary foods like beans and rice at every meal to get enough protein has been disproven [source]. There is now sufficient evidence that plant-based diets can provide enough protein even for endurance athletes [source].
Amino acid supplementation has become increasingly common for a range of reasons. Branched-chain amino acids (BCAA) are popular for athletic training and muscle repair and seems to help with soreness following exercise [source], although there is limited evidence that they enhance performance [source], whereas essential amino acids such as tryptophan [source] and phenylalanine are being used to improve mood, energy, and quality of sleep.
There is some evidence that BCAAs may contribute to high blood pressure, although the studies are conflicting [source]. Even nonessential amino acids such as glutamine have become popular fitness and wellness supplements, although there seems to be little to no evidence supporting this in recent reviews [source].
Current research on the validity of amino acid supplementation is a bit complicated, and we haven’t yet seen the impacts of long-term supplementation. It does seem that most amino acid supplements are generally safe in the recommended dosages and for the appropriate indications. However, since amino acids are the building blocks for proteins, excessive consumption may have adverse metabolic effects.
Starting an amino acid supplement on top of an already balanced diet is something you should discuss with your healthcare provider to review the need for it, all available options, and any concerns regarding your health history.
Photo by Alison Marras on Unsplash
This article was medically reviewed by Dr. Gina Jansheski, a licensed, board-certified physician who has been practicing for more than 20 years. Learn more about Hello Glow’s medical reviewers here. As always, this is not personal medical advice and we recommend that you talk with your doctor.
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I have been curious about this because I have been taking amino acids now for a little while every single day. I am a veganish-vegetarian, so I don’t get a lot of meat based amino acids. I also don’t think my diet gets all of them. So now I am ordering a bunch in bulk powder. Are they working? Or is this placebo? Can I take a bunch all at once in the same water? Don’t some compete for absorption this way? It’s all so confusing. Do they help or am I wasting all this money? I also workout now so I am learning about which ones to take before and after a good workout to help metabolism and muscle formation and repair. Or so I read. It could be advertising that plays a role in amping up a certain product to sell. I wish this article went into more depth, although it was nice to learn how proteins are disassembled into amino acids and reassembled into what is needed at the time. I just had assumed the extra amino acids we don’t need but supplement with just get peed out? Or do they harm?
Actually Nucleic acids are a specific arrangement and structure of combined amino acids in a modified form. DNA can and is broken down to amino acids. Modifications and genetic mutations are caused by modifications to amino acids which are the fundamental building blocks of nucleic acids( a specific kind of protein). She was right and just simplified without explaining information that others cannot interpret for themselves without biological and chemical knowledge.
Amino Acids are carbon structures with at least a amine group and carboxyl group. Both of which are present in all base pairs of nucleic acids. In other words DNA is just a combination of modified amino acids into specific arrangement and structures which we name as ATCG.
Thanks for a great post. I was looking for some insight into the use of protein supplements and this post nicely lays out key aspects to consider, as well as things I did not know. I am not a food expert, so your post really helps me to understand what is going on.
One small feedback: I just want to point out that DNA is not composed of protein – mentioned in your first paragraph… They are composed of nucleic acid (hence the name DNA – Deoxyribonucleic acid) and they have completely different chemical structure. Normally, I would have just pressed back-page and not care about it as soon as I saw that statement. But for some reason, I fully read your post and liked how you explained things. So, I just wanted to point that out for you because some people who has taken basic biology or biochemistry (which is a lot of people, these days) will know that protein and nucleic acids are different and might not even read your post. This is a genuine feedback for better quality nutritional posts around the internet. I hope you take it as a constructive feedback.
Again, thanks for the great post!
Cheers,
Ordinary Chemist passing by…